Fish, who won in Newport earlier this month, took the first four points of the tiebreaker. Isner rallied to win the next three points but couldn't pull even.
With temperatures in the mid-90s, the match lasted 2 hours, 45 minutes. The on-court temperature hovered near 150 degrees.
Americans Scott Lipsky and Rajeev Ram beat Rohan Bopanna of India and Kristof Vliegen of Belgium 6-3, 6-7 (4-7), 12-10 in the doubles final. Lipsky and Ram did not lose a set until the final.
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2011 US Open